BACK GROUND AND OBJECTIVES: Free radicals, reactive oxygen species play an important role in the pathogenesis of atherosclerosis causes Coronary Heart Disease (CHD). Antioxidant present in our diet such as vitamin C, vitamin E and b-Carotene may act against the free radicals. Thus they can prevent the process of atherosclerosis and CHD. Object of this study was to determine the serum antioxidant vitamin C and lipid profile in CHD patients.DESIGN AND SETTING FOR STUDY: At Shaikh Zayed Hospital and Punjab Institute Of Cardiology, Lahore.SUBJECT AND METHODS: We have measured the Antioxidant vitamin C concentration and lipid profile in the case controlled study of 80 patients of CHD; and 21 Healthy Control Subjects by matching their age, sex, weight and height with respect to those of CHD patients.RESULTS: No significant (P> 0.05) difference was observed in the mean serum vitamin C level in the CHD patients and control subjects. Regarding lipid profiles; significant raised triglycerides, total cholesterol and LDL-cholesterol and significant decreased HDLcholesterol were observed when compared CHD patients with normal subjects. CONCLUSION: No doubt nutrient oxidants are better for preventing CHD, but this study showed no correlation between antioxidant vitamin C level and Coronary Heart Disease (CHD). So there is need to carry out a wide study of antioxidant (Vitamin C) level in Coronary Heart Disease