Purpose  of  study:  To  evaluate  the  hepato-protective  activity  of  methanolic extract of Melia Azedarach (Root) in ccl4 induced liver damage in rats. Material  &  Methods:  Serum  levels  of Alanine  amino-transferase, Alkaline Phosphatase, Bilirubin and Gamma-GT were analyzed in rats after treatment with extract of Melia Azedarch’s root followed by administration of CCl4 in order to assess the preventive effect of extract on liver damage. In addition, the levels of the enzymes in rats administered with ccl4 followed by 14 days treatment with  the  plant  extract  were  determined  in  order  to  assess  the  cure  of  liver damage. In the extract treated animals, there was significant decrease in liver enzyme levels. Results: This observation leads to the conclusion that melia flower extract possesses hepato protective activity. The hepato protective activity of the methanolic extract was compared with standard poly herbal formulation named Jigrine CL. The extract of Melia Azedarch’s root was screened for hepato protective effect. Albino rats were administered with carbon tetra chloride (CCl4) for inducing liver damage. Conclusion: It was concluded that the extract of Melia Azedarach found effective against CCl4 induced liver damage