Introduction: Cardiac diseases pose dangerous and debilitating effects on human beings affecting all age group members. Pakistan, like other South Asian countries, has a higher prevalence of Cardio-vascular risk factors as compared to other parts of the world, due to lack of awareness towards the risks as the literacy rate in our country is below 50%. Basic aim of our study was to detect the health status & life-style of medical students from Karachi & Jamshoro-Hyderabad, by finding out the BMI, stress level, physical activity and fast food habits. Materials and Methods: Students of M.B.B.S. aged between 18 to 29 years were chosen. Structured questionnaire-based cross- sectional study was conducted on 400 of L.U.M.H.S.& D.U.H.S. The BMI was calculated in metric system, categorized into 5 categories. Further, students were asked to mention their routine physical work output (walk and exercise); maximum stress taken during the ongoing year, and note down their habits of eating out on the form. Results: B.M.I of both groups was mostly in normal range with 68.9% from D.U.H.S and 59.4% from L.U.M.H.S. Yet, the underweight population of D.U.H.S. and overweight population of L.U.M.H.S was higher giving rise to a significant variation (p=0.021). Routine walking habits of most L.U.M.H.S scholars were more prominent than their counter parts from D.U.H.S. (p=0.034). Exercise was found to be another significant factor in which L.U.M.H.S participants were ahead (p=0.000).No significant variation (p=0.250) was seen in students, from L.U.M.H.S. & D.U.H.S., with regard to maximum stress episodes experienced during the on-going year. Students  from  both  universities  mostly  preferred  going  to  fast  food  once  a month. Conclusion: B.M.I of L.U.M.H.S. students was higher than that from D.U.H.S. Exercise and routine walking habits varied significantly amongst two groups. The difference occurred due to more female candidates studying at D.U.H.S., than in L.U.M.H.S., whose BMI was observed to be quite low than males over there. Also, transportation and distance of students from their institute to their residence did let to this variation in the data achieved in walking habits. No variation was seen in stress level and eating out habits.